Parkinson's disease

Parkinson's disease, or simply Parkinson's, is a neurodegenerative disease primarily of the central nervous system, affecting both motor and non-motor systems. Symptoms typically develop gradually, with non-motor issues becoming... Wikipedia

• Symptoms:  Main: Tremor, bradykinesia, rigidity, postural instability (collectively known as parkinsonism), Other: Dysautonomia, depression, anxiety, sleep abnormalities
• Complications:  Falls, dementia, aspiration pneumonia
• Usual onset:  Age over 60
• Duration:  Long-term
• Risk factors:  Family history, dyspepsia, general anesthesia, pesticide exposure, head injuries
• Diagnostic method:  Symptomatic, medical imaging
• Differential diagnosis:  Dementia with Lewy bodies, progressive supranuclear palsy, essential tremor, antipsychotic use, fragile X-associated tremor/ataxia syndrome, Huntington's disease, dopamine-responsive dystonia, Wilson's disease
• Prevention:  Physical activity, nicotine, caffeine
• Treatment:  Physical therapy, deep brain stimulation
• Medication:  L -DOPA, COMT inhibitors, AAAD inhibitors, dopamine agonists, MAO-B inhibitors
• Prognosis:  Near-normal life expectancy
• Data source:  DuckDuckGo